Injectable HRT

Some transgender, nonbinary and gender-diverse people will begin hormone replacement therapy, also known as gender-affirming hormone therapy (GAHT) as a way to begin to live their lives authentically. Some people choose injections as their method for taking testosterone or estrogen/estradiol.

Is it better to take HRT injection or pill?
In general, transdermal or injected estrogen treatment is thought to be safer than oral treatment. This is because there is no hepatic first pass effect. Topical and injectable estrogens also need to be taken less often, which may make dealing with them easier.